| Unlock Condition |
Unlock
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| Complete the tutorial.
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 - Pea Shooter
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| Find Ser Manuel's remains in the tutorial.
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| Start 6 runs.
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Sprun
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| Defeat the High Dragun.
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| Defeat the High Dragun five times.
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 - Old Knight's Flask
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| Defeat the boss of the Keep of the Lead Lord without getting hit.
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 - Shield of the Maiden
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| Defeat the boss of the Gungeon Proper without getting hit.
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 - Iron Coin
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| Defeat the boss of the Black Powder Mine without getting hit.
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 - Hazmat Suit
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| Defeat the boss of the Hollow without getting hit.
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 - Frost Giant
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| Complete the Keep of the Lead Lord 50 times.
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 - Brick Breaker
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| Complete the Gungeon Proper 40 times.
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 - Staff of Firepower
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| Complete the Black Powder Mine 30 times.
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 - Mine Cutter
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| Complete the Hollow 20 times.
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 - Polaris
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| Complete the Forge 10 times.
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| Build the Bullet That Can Kill The Past.
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| Kill The Convict's past.
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| Kill The Hunter's past.
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| Kill The Marine's past.
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| Kill The Pilot's past.
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| Reach The Cultist's past.
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Number 2
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| Reach The Cultist's past, or defeat the High Dragun with a companion.
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Sunlight Javelin
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| Kill the pasts of all four main Gungeoneers.
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 - Gilded Hydra
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| Kill The Bullet's past.
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 - Chicken Flute
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| Kill The Robot's past.
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| Kill The Gunslinger's past.
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Lich's Eye Bullets
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| Reach the Oubliette.
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 - Trashcannon
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| Reach the Abbey of the True Gun.
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 - Blood Brooch
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| Reach the Resourceful Rat's Lair.
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 - Weird Egg
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| Defeat Blobulord.
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 - Super Space Turtle
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| Defeat Old King.
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 - Bloodied Scarf
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| Defeat the Resourceful Rat's first two phases.
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| Defeat Agunim in the R&G Dept.
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Katana Bullets
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| Defeat Blockner.
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| Defeat the Lich.
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| Spare 5 Red-Caped Bullet Kin.
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 - The Bullet
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| Bring the Busted Television to the Blacksmith.
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 - The Robot
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| Find and interact with a cosmic rift after defeating the past of any of the 4 main Gungeoneers, then defeat the Lich.
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 - The Paradox
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| As The Paradox, defeat the Lich, then kill the Gunslinger's past on the next run.
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 - The Gunslinger
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Kill 10 Confirmed
or teleport to the eyeball room with Teleporter Prototype.
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 - Yellow Chamber
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| Kill 15 Keybullet Kin.
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 - Springheel Boots
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| Kill Shadow Magician.
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 - Bottle
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| Kill Shadow Magician 5 times.
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 - Cursed Bullets
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| Get grabbed by a Gripmaster.
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 - Daruma
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| Get caught by a Tarnisher.
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 - Hungry Bullets
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| Push a table into a pit.
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 - Table Tech Rocket
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| Kill 100 enemies by pushing them into pits.
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 - Amulet of the Pit Lord
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Carry 300  at once.
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 - Coin Crown
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| Steal 10 items from the Shop.
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 - Shelleton Key
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| Create 10 guns with Munchers.
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| Feed 10 guns to Evil Munchers.
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 - Gunslinger's Ashes
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| Acquire 5 Master Rounds in one run.
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 - Super Hot Watch
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| Use Lament Configurum 20 times.
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 - Bloody 9mm
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| Attack a mimic before it attacks.
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 - Book of Chest Anatomy
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| Kill a jammed boss.
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 - Sixth Chamber
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| Defeat the High Dragun with Beastmode on.
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 - Bait Launcher
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| Defeat the High Dragun as The Bullet.
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 - Blasphemy
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| Defeat the High Dragun as The Robot.
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 - Battery Bullets
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| Defeat the High Dragun with the Sorceress's blessing.
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 - Gunther
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| Defeat the High Dragun in Turbo Mode.
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 - Crisis Stone
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| Defeat the High Dragun while having the Super Space Turtle.
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Turtle Problem
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| Defeat the High Dragun as The Paradox.
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The Fat Line
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| Defeat the Advanced Dragun.
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 - Holey Grail
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| Reach the Black Powder Mine in Challenge Mode.
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 - Chance Bullets
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Defeat the High Dragun in Challenge Mode
or attempt Challenge Mode 30 times.
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 - Chaos Bullets
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| Complete Boss Rush.
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 - Bracket Key
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| Transport Ox's replacement arm back up to the Breach.
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 - Clone
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| Win ten of the Gunsling King's wagers.
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 - Owl
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| Map out the first five chambers for The Lost Adventurer.
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 - Excaliber
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| Ace Winchester's game three times.
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 - Seven-Leaf Clover
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| Rescue the Ledge Goblin four times.
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 - Blast Helmet
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| Rescue Daisuke.
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 - Lament Configurum
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| Give health to the Vampire 3 times.
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 - Wood Beam
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| Purchase from Synergrace 3 times.
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 - Macho Brace
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| Fully populate The Breach.
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 - Unity
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| Have two companions at once.
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 - Battle Standard
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| Find Ser Junkan, upgrade him to Knight or higher, then kill a boss.
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 - Ser Junkan
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| Destroy a red, black, or rainbow chest.
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 - Gold Junk
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| Find and use a Glass Shrine.
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 - Glass Guon Stone
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| Use 2 Companion Shrines.
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 - Turkey
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| Use 2 Blood Shrines.
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 - Life Orb
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| Roll over tables 50 times.
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 - Portable Table Device
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| Find High Dragunfire in a Secret Room.
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 - High Dragunfire
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Find the items in a shop and pick them up,
either by stealing them or making the shopkeeper close his shop.
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Each of these items must be unlocked separately.
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| Open the Resourceful Rat's chests after defeating him.
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Each of these items must be unlocked separately.
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| Finish a run with Baby Good Mimic.
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Baby Good Shelleton
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| Complete shortcuts.
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See Shortcuts for details.
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| Complete Hunting Quests.
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See Frifle and the Grey Mauser for details.
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Purchase items and guns with  from Ox and Cadence.
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See Ox and Cadence for details.
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| Purchase items and guns with from Trorc in The Breach.
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See Trorc for details.
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| Purchase items and guns with from Professor Goopton in the Breach.
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See Professor Goopton for details.
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| Purchase items and guns with from Doug in the Breach.
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See Doug for details.
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| Unlock every Gun and Item in the Ammonomicon.
|
 - Finished Gun
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